| Catalog Number： |
A98150 |
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CAS No.: |
1668553-26-1 |
| MDL: |
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Formula: |
C46H55N7O7S |
| F.W.: |
850.04 |
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Purity: |
99％ |
| Package: |
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Unit: |
mg |
| Appearance: |
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M.P.: |
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| B.P.: |
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Density: |
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| Optical Rotation: |
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Refractive Index: |
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| Solubility: |
Soluble in DMSO |
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Stability: |
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| Storage: |
Store at 0°C (short term), -20°C (long term) |
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Category: |
Reference Standard |
| Reference: |
Zhong, Q., et. al.: Cell, 121, 1085 (2005); Opferman, J.T., et. al.: Science, 307, 1101 (2005);JD Leverson, et al, Potent and selective small-molecule MCL-1inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263(navitoclax), Cell Death & Disease (2015) 6, e1590; doi: 10.1038/cddis.2014.561 |
| Application: |
Abbvie Mcl-1 Inhibitor is an inhibitor of Mcl-1 where Mcl-1 is an anti-apoptotic.A-1210477 is a proteolytically stable, cell-permeable and high affinity BH3 mimetics of anti-apoptotic protein MCL-1, binding to the target potently and selectively with a Ki value of 0.45 nM, highly selective against closely related proteins of BCL-2 (Ki = 132 nM, >290-fold selectivity) and BCL-XL (Ki > 660 nM, >1400-fold selectivity). A-1210477 is the first-in-class small molecule MCL-1 inhibitor with sufficient potency to disrupt the tight-binding MCL-1-BIM complex in living cells, achieving the hallmarks of intrinsic apoptosis, and demonstrating clear-on-target cancer cell killing capability either as a single agent or in combination with ABT-263 (Navitoclax). |
| Category: |
Aromatics, Inhibitors, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds |
