Catalog Number: |
I00001 |
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CAS No.: |
872511-34-7 |
MDL: |
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Formula: |
C26H31Cl2N7O3 |
F.W.: |
560.49 |
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Purity: |
99% |
Package: |
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Unit: |
mg |
Appearance: |
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M.P.: |
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B.P.: |
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Density: |
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Optical Rotation: |
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Refractive Index: |
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Solubility: |
In DMSO, water with 1 eq. of acid |
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Stability: |
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Storage: |
Store at 0°C (short term), -20°C (long term) |
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Category: |
Reference Standard |
Reference: |
Vito Guagnano, et al, Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), A Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor Tyrosine Kinase, J. Med. Chem., 2011, 54 (20), pp 7066–7083 |
Application: |
NVP-BGJ398 is a potent, selective and orally active pan-FGFR inhibitor, with IC50s of 0.9, 1.4, 1.0 and 60 nM for FGFR1, 2, 3 and 4, respectively. |
Category: |
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