Saxagliptin Intermediate I |
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| Synonyms: tert-Butyl (1R,3S,5R)-3-Carbamoyl-2-azabicyclo[3.1.0]hexane-2-carboxylate ; (1R,3S,5R)-3-(Aminocarbonyl)-2-azabicyclo[3.1.0]hexane-2-carboxylic Acid 1,1-Dimethylethyl Ester | |
| Cat. No.: S12053 | CAS No.: 1445592-86-8 |
| MDL.: | Formula: C11H18N2O3 |
| F.W.226.27 | Purity: 99% |
| Storage: | |
| Size/Unit | Price | Qty | Availability | Price Total |
|---|---|---|---|---|
| 10mg | $150.00 | Enter qty and click checkbox |
 
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$150.00 |
| Catalog Number： | S12053 | CAS No.: | 1445592-86-8 | |
| MDL: | Formula: | C11H18N2O3 | ||
| F.W.: | 226.27 | Purity: | 99% | |
| Package: | Unit: | mg | ||
| Appearance: | M.P.: | |||
| B.P.: | Density: | |||
| Optical Rotation: | Refractive Index: | |||
| Solubility: | Stability: | |||
| Storage: | Category: | Reference Standard | ||
| Reference: | Dong, J., et al.: Bioorg. Med. Chem., 22, 1383 (2014); Feng, J., et al.: J. Med. Chem., 50, 2297 (2007); Rosenstock, J., et al.: Diabetes Obes. Metab., 10, 376 (2008); Thomas, L., et al.: J. Pharmacol. Exp. Ther., 325, 175 (2008) | |||
| Application: | tert-Butyl (1R,3S,5R)-3-Carbamoyl-2-azabicyclo[3.1.0]hexane-2-carboxylate is an intermediate in the synthesis of ((2S,2R’,trans)-Saxagliptin, which is an impurity of Saxagliptin. Saxagliptin is a potent and selective reversible inhibitor of dipeptidyl peptidase-4 (DPP-IV) developed for the treatment of type 2 diabetes. | |||
| Category: | Amines, Chiral Reagents, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals | |||