Apitolisib (GDC-0980) |
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Synonyms: (S)-1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one | |
Cat. No.: A64400 | CAS No.: 1032754-93-0 |
MDL.: | Formula: C23H30N8O3S |
F.W.498.6 | Purity: 99% |
Storage: | |
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Catalog Number: | A64400 | CAS No.: | 1032754-93-0 | |
MDL: | Formula: | C23H30N8O3S | ||
F.W.: | 498.6 | Purity: | 99% | |
Package: | Unit: | mg | ||
Appearance: | M.P.: | |||
B.P.: | Density: | |||
Optical Rotation: | Refractive Index: | |||
Solubility: | DMSO | Stability: | ||
Storage: | Category: | Reference Standard | ||
Application: | GDC-0980 (RG7422) is a selective, potent, orally bioavailable inhibitor of Class I PI3 kinase and mTOR kinase (TORC1/2) with in vitro IC50 of 5, 27, 7 and 14 nM for p110 a, ß, d and ? isoforms, respectively. |